Blood-brainbarrier modulation and low-level exposure to xenobiotics Academic Article uri icon


  • Separation of the brain from the peripheral blood is crucial for protecting this most delicate and important organ from various insidious agents that circulate in the blood. Conversely, the separation must allow for the nutrition of the brain and the removal from it of waste products. The existence of a physical barrier that separates the brain tissue from the general circulation was first proposed 100 years ago, by Ehrlich, who discovered that injection of a series of dyes into laboratory animals resulted in uncolored brains, as opposed to highly …

publication date

  • December 7, 2000