Lesion-symptom mapping of the human cerebellum Academic Article uri icon


  • Although the function of the cerebellum cannot be inferred from lesion data alone, it is still of major scientific and clinical interest to assess whether lesions of a given cerebellar area lead to specific behavioral deficits. The introduction of high-resolution structural brain imaging and new analysis methods has lead to significant improvement in the ability to draw such conclusions. Lesion-symptom mapping is now possible with a spatial resolution at the level of individual lobules and nuclei of the cerebellum. The investigation of patients with defined focal lesions yields the greatest potential for obtaining meaningful correlations between lesion site and behavioral deficits. In smaller groups of patients, overlay plots and subtraction analysis are good options. If larger groups of patients are available, different statistical techniques have been introduced to compare behavior and lesion site on a …

publication date

  • January 1, 2013