- Prostate cancer is one of the most common types of cancer and it is the second most common cause of cancer-related death among men in the western world. Microscopic prostate cancer was found in up to 30% of men as early as 20-40 years old of age. Lycopene is a lipid soluble carotenoid molecule. It is found in high concentration in red fruit and vegetables. Lycopene has a significant anti-oxidative activity. There is laboratory evidence that explain it's function as an inhibitor of various tumors as well as epidemiological evidence that shows that lycopene-rich foods reduce the incidence of a few types of cancer and especially prostate cancer. This paper reviews the evidence that explain lycopene activity, its biological effect and availability and its effect on the prevention of prostate cancer.