Renal safety and angiotensin II blockade medications in patients undergoing non-emergent coronary angiography: a randomized controlled study. Academic Article uri icon


  • BACKGROUND: Contrast-induced nephropathy (CIN) is one of the major causes of new- onset renal failure in hospitalized patients. Although renin-angiotensin-aldosterone system (RAAS) blocking agents are widely used among patients requiring contrast studies, data on the effect of these agents on the development of CIN are sparse and inconsistent. OBJECTIVES: To evaluate in a randomized controlled trial whether uninterrupted administration of angiotensin II (AnglI) blockade medications influence estimated glomerular filtration rate (eGFR) in patients undergoing non-emergent coronary angiography. METHODS: Patients receiving treatment with angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACE-I/ARB) were recruited consecutively. The enrolled subjects were randomized into three groups at a 1: 1: 1 ratio: group A (ACE/ARB …

publication date

  • January 1, 2013