146: Advanced maternal age and the risk for long-term malignant morbidity in the offspring Academic Article uri icon


  • Objective Advanced maternal age has been associated with several short and long-term adverse maternal and perinatal outcomes. We sought to determine whether advanced maternal age is independently associated with an increased risk of childhood cancers in the offspring. Study Design A retrospective cohort study of all women who delivered at the Soroka University Medical Center (SUMC) between the years 1991 and 2014 was conducted. Elderly parturients (≥ 35 years) were divided into: 1) 35-39 years and 2) 40-50 years, and compared to parturients aged 20-34 years. Outcome included all hospitalizations of the offspring up to the age of 18 years involving malignant morbidity, according to a set of predefined oncological ICD-9 codes. A Kaplan-Meier Survival curve was used to compare cumulative malignant morbidity incidence of the offspring in all maternal age groups. A …

publication date

  • January 1, 2018