Measles virus: evidence of an association with Hodgkin's disease. Academic Article uri icon

abstract

  • An association between Hodgkin's disease (HD) and infection with Epstein–Barr virus (EBV) is now well established on the basis of immunohistochemical (IHC) and in situ hybridisation (ISH) studies, and causal implications of this association have been inferred (Knecht et al, 2001; Niedobitek et al, 2001; Jarrett, 2002). Young adult HD patients from a high socioeconomic environment do not, however, usually have an EBV-associated disease (Alexander et al, 2000), although epidemiological evidence suggests that this age group is the one whose HD is most expected to be related to late exposure to a common infectious agent (Gutensohn and Cole, 1981; Glaser, 1990; Westergaard et al, 1997; Sleckman et al, 1998; Glaser et al, 2002). Evidence of delayed exposure to EBV is present in only a minority of these young adult HD patients (Jarrett, 2002). The suggestion that EBV-negative cases of HD had previously been EBV positive (the hit-and-run hypothesis) or that a defective EBV genome is integrated in the chromosomal DNA of EBV-negative tumour cells in HD has not been confirmed (Delecluse et al, 1997; Brousset, 2002; Gallagher et al, 2003).

publication date

  • January 1, 2004