Aqueous enantioselective hydrogenation of methyl 2-acetamidoacrylate with Rh-MeDuPHOS occluded in PDMS Academic Article uri icon

abstract

  • Over the past 30 years, 1 economic incentives 2 and scientific challenges have led to significant progress in the R&D of enantioselective homogeneous and heterogeneous catalysts for the production of pure enantiomers from prochiral substrates. Transition metal complexes with biphosphine ligands, such as BINAP [2,2-bis(diphenylphosphino)-1,1′-binaphthyl] 3–5 and DuPHOS [1,2-bis(phospholano)benzene], 6–8 have proved to be excellent homogeneous catalysts in various asymmetric hydrogenation reactions. Attempts have been made to heterogenize these complexes so as to combine advantages of heterogeneous catalysts (high stability, facile catalyst recycling, and the possibility for continuous operation) with the inherent advantages of homogeneous catalysis (high activity and enantioselectivity) … Most organic chemical reactions take place in organic solvents, but the advantages of being able to use water as the solvent are self …

publication date

  • January 1, 2002