Premedication with non-selective and M₁-selective muscarinic antagonists before ECT. Academic Article uri icon


  • Compared the effects of premedication using atropine, a non-selective muscarinic antagonist, with biperiden, an M₁-selective muscarinic antagonist. Cardiac rate and other cardiac parameters and respiratory tract secretions after ECT were compared in 8 patients (aged 23–67 yrs), with Diagnostic and Statistical Manual of Mental Disorders-III-Revised (DSM-III-R) diagnoses of unipolar depression or schizophrenia, to determine whether atropine effects following ECT involve central or peripheral antagonistic effects. Results show that in preventing excessive sialorrhea following ECT, atropine works antagonistically through peripheral glandular M₂ receptors whereas biperiden antagonizing M₁ receptors fail to prevent sialorrhea. Findings are not conclusive concerning cardiac protective effects of atropine following ECT.(PsycINFO Database Record (c) 2016 APA, all rights reserved)

publication date

  • January 1, 1993