- Pasteurella multocida is the causative agent of numerous economically relevant diseases worldwide. Pasteurella multocida has been known to cause infections in humans, the most familiar being soft tissue infection after animal bites. Systemic infections are rare and endocarditis is exceptionally rare. We report about a 72 year old woman with prosthetic biologic aortic valve was admitted to West Galilee Naharia Hospital because of 10 days long fever after a domestic cat scratch in her left palm. During her stay the patient continued to have spiking fever accompanied by shivering despite the antibiotic therapy, she had worsening dyspnea, tachypnea, feet edema and cough. Due to the findings listed above another trans thorathic echocardiography was performed on the 11th day of her hospitalization, which showed endocarditis of the prosthetic aortic. On the 42nd day an MRI exam was done that showed an inflammatory process that involved the l5-s1 vertebras and the intervertebral disc. We believe our report is the second documented case of Pasteurella multocida endocarditis that was complicated by osteomyelitis, and we contemplate upon this rare occurrence and its implications.