The effect of a closed head trauma on blood Glutamate levels Academic Article uri icon


  • Materials and methods: After approval of the Animal Care Committee, spontaneously breathing 24 male Sprague Dawley rats weighing 200–300 g were anesthetized with 2% isoflurane and a cranial impact of 0.5 J was delivered by a rod. Blood G was measured using a spectrofluorometric assay (Graham and Aprison). Values are presented as mean±standard deviation. Results: Figure shows that the CHT causes a significant decrease of blood G levels as measured after 1 h. At 90 and 120 min, an increase is observed and attributed to a compensatory efflux into blood of G from peripheral organs including the brain that sense the decerase in blood G levels.

publication date

  • January 1, 2006