- Dobutamine stress echocardiography (DSE) is an accurate noninvasive test used for the diagnosis and evaluation of patients with known or suspected coronary artery disease (CAD). The aim of this study was to determine the rate of positive e ndings in DSE, to dee ne the echocardiographic and clinical characteristics of women with systemic lupus erythematosus (SLE) and to evaluate the safety of DSE in SLEpatients. Thirty consecutive SLEpatients were enrolled in the study and underwentDSEstudy. The mean age of patients was 44 years (range 20‐ 76). Mean duration of SLE was 8.1 years and mean SLEDAI was 5.5. None of the DSE tests performed were positive for myocardial ischaemia. A left ventricular oute ow gradient (LVOG) was found in 15 /28 (54%) patients who completed the test, a result higher than the reported 20% prevalence of this e nding in the literature. There were no signie cant differences in baseline characteristics between patients who developed a gradient and patients in whom a gradient was not found. There were no signie cant adverse effects during the study. In the general population, LVOG has been reported to be associated with an increased rate of chest discomfort and with a signie cantly lower prevalence of CAD. Whether this is true for SLE patients requires further study. Lupus (2004) 13, 101‐104.