Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigi... Academic Article uri icon


  • Diacylglycerol lactones built with a rigid 4-[(methylphenyl) ethynyl] phenyl rod that is separated from the exocyclic acylcarbonyl of the DAG-lactone core by a spacer unit of variable length were synthesized and studied. Binding affinities for a panel of classical and novel PKC isozymes in two different phospholipid environments, one corresponding to the plasma membrane of cells, were determined. The kinetics and site of translocation for the PKC isozymes R and δ upon treatment with the compounds were also studied as well as …

publication date

  • April 20, 2009