- Materials and Methods: Two liters of dialysis solution were infused over 10 minutes into 18 patients with stage V chronic kidney disease. Blood samples were collected immediately prior to initiation of PD, and hourly for a total of 5 blood samples. Blood samples were sent for determination of glutamate, creatinine, urea, glucose, glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT). PD samples were collected and analyzed for glutamate, creatinine, urea and glucose at the same time points as the blood samples. Results and Discussion: Blood glutamate concentrations were significantly reduced by 60 minutes after the infusion of dialysis solution and remained decreased throughout the experiment (p< 0.0001), whereas levels of glutamate in the dialysis solution were increased significantly by 60 minutes (p< 0.0001)(Figure 1).