Sieve analysis of HIV sequences in vaccine efficacy trials Academic Article uri icon

abstract

  • Sieve analysis is integral to the evaluation of immune correlates of protection, as vaccine- induced immune responses (whether measurable or not) are the cause of vaccine sieve effects.(Vaccine sieve effects are vaccine-induced adaptive immune responses that may partially block HIV acquisition, and/or alter HIV's evolution postacquisition.) Sieve analysis can shed light on potential mechanisms of immune protection, as well as generate hypotheses on which immunological measurements may be immune correlates.The enormous variability of the HIV genome and the spread of multiple HIV genotypes and recombinants has posed a difficult challenge to developing a vaccine. 1, 2, 3 In preventive HIV vaccine efficacy trials, HIV sequences are measured and characterized from trial participants who become infected. Sieve analysis of these HIV sequences investigates …

publication date

  • January 1, 2011