Quantifiable predictive features define epitope-specific T cell receptor repertoires Academic Article uri icon

abstract

  • Abstract T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that mediates recognition of pathogen-associated epitopes through interactions with peptide and major histocompatibility complexes (pMHCs). TCRs are generated by genomic rearrangement of the germline TCR locus, a process termed V (D) J recombination, that has the potential to generate marked diversity of TCRs (estimated to range from 10 15 (ref. 1) to as high as 10 61 (ref. 2) possible receptors). Despite this potential diversity, TCRs from T …

publication date

  • July 1, 2017

published in