Highly sensitive SERS based nano-sculptured thin film biosensor for the detection of vitellogenin: an endocrine disruption biomarker Conference Paper uri icon


  • Abstract: A biosensor has been fabricated by using the SERS of 4-Aminothiophenol (4-ATP) on optimized nano-sculptured thin films (nSTFs) of silver over Si substrates. The limit of detection is as small as 5 pg/ml of vitellogenin. OCIS codes: (130.6010) Sensors, (240.6695) Surface-enhanced Raman scattering, (280.1415) Biological sensing and sensors, (250.5403) Plasmonics, (220.4241) Nanostructure fabrication … 1. Introduction The Raman spectroscopy signals are known to get enhanced by a factor of several orders of magnitude when brought in contact with corrugated metal surfaces. This enhancement in intensity is termed as surface enhanced Raman scattering (SERS) and attributed to the highly localized fields of surface plasmons. SERS enhancement is basically controlled by the material, size, shape, orientation, porosity, and the substrates on which the nanostructures are deposited. Various kinds of nanostructures, such as …

publication date

  • January 1, 2014