Nanoparticle-Assisted Stimulated-Emission-Depletion Nanoscopy Academic Article uri icon


  • We show that metal nanoparticles can be used to improve the performance of super- resolution fluorescence nanoscopes based on stimulated-emission-depletion (STED). Compared with a standard STED nanoscope, we show theoretically a resolution improvement by more than an order of magnitude, or equivalently, depletion intensity reductions by more than 2 orders of magnitude and an even stronger photostabilization. Our scheme may allow improvement of existing STED nanoscopes and assist in the development of low-power, low-cost nanoscopes. This has the potential to increase the availability of STED nanoscopes and lead to a significant expansion of our understanding of biological and biochemical phenomena occurring on the nanoscale.

publication date

  • January 1, 2012