85. Deep repetitive transcranial magnetic stimulation with H-coil for motor symptoms in Parkinson’s disease: A randomized, double blind, placebo-controlled study Academic Article uri icon


  • To evaluate the effect of repetitive deep transcranial magnetic stimulation—rDTMS on motor symptoms in Parkinson’s Disease—PD in a randomized, placebo controlled study. Sixty patients underwent 12 sessions (3 sessions/week) of 10 Hz rDTMS, after randomization into 3 groups: Group 1 (real rDTMS on primary motor—M1 and prefrontal—PF areas); Group 2 (M1-real/PF-sham), Group 3 (M1-sham/PF-sham). Primary outcome was percent reduction of Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part III, OFF therapy. Secondary outcomes were: changes in UPDRSIII sub-scores; improvement in timed tests (Hand Tapping—HT, Foot Tapping—FT, Walking Time—WT, Nine Hole Peg Test—NHPT). Statistical analysis was performed using Mann–Whitney or t -test. Outcomes were tested in hierarchical order, by comparing the two real groups (1–2) only if their pooled data significantly differed from sham. No drop-outs or serious adverse effects were recorded. Both real groups improved significantly more than sham in UPDRSIII ( p = .010 and p = .045, respectively), while they did not significantly differ between them. Pooled real groups showed a significant improvement vs sham in UPDRSIII ( p = .007), tremor ( p = .011) and lateralized sub-scores ( p = .042 and p = .012 for worse and better side, respectively). Timed tests significantly improved more in the real group vs sham on the worse side (HT p = .041, FT p = .012, NHPT p = .003). rDTMS with H-coil appeared safe and effective on motor symptoms as add-on treatment in PD.

publication date

  • January 1, 2015