TPA activates p21 WAF-1 promoter in human T-cells through its second most upstream Sp1 site Academic Article uri icon


  • The p21WAF-1 promoter contains binding sites for a number of transcription factors which mediate its activation by a variety of external signals. Moreover, it has been reported that the transcription factors involved in p21WAF-1 activation by certain signaling factors, like the phorbol ester TPA, may vary in different cell types. We were interested in elucidating the mechanism of p21WAF-1 activation by TPA in human T-cells, since this activation could explain the antagonistic effect of PKC on apoptosis induction in these cells noted in our …

publication date

  • May 16, 2003