- Background: Enetrubius vermicularis infection, or in its' other name – Oxyuris, is the most common type of infection from a parasite in Western Europe and the United States. Most individuals with Enterobius Vermicularis do not have any symptoms. Oxyuris is considered a rare pathogen and an atypical cause for appendicitis. Laparoscopic appendectomy is the most frequent on-call surgery done as an emergency. We tried to evaluate the effect of this rare cause of appendicitis upon outcomes after appendectomy for acute appendicitis in adults. Methods: After obtaining approval of our institutional review board, a retrospective cohort study using the records of all our patients who underwent laparoscopic appendectomy. Adult patients with suspected acute appendicitis who underwent a laparoscopic appendectomy or a diagnostic laparoscopy were enrolled. The medical records of patients who underwent a laparoscopic appendectomy for suspected acute appendicitis between 2000 and 2010 in Surgery A at Soroka University Medical Center, Beer Sheva, Israel, were reviewed retrospectively. 810 eligible subjects were admitted with suspected appendicitis. In this retrospective study of patients who underwent laparoscopic appendectomy in our department between 2000 and 2012 was conducted, and either had a regular cause for appendicitis (the control group), or appendicitis due to Enterobius vermicularis (the parasite group). The patients were operated on by novice surgeons, chief residents, and senior surgeons. Pre-operative variables were compared, as well as surgical outcomes and complications. Results: Our study had more than 800 patients enrolled, of them a sample of 93 control patients and 3 patients in the parasite group. In uni-variate analysis we found no connection between suffering from appendicitis due to Enetrubius vermicularis and "regular" causes of appendicitis, as seen in demographics and intra and post-op complications. Conclusions: In our retrospective study, parasitic cause acute appendicitis in adults does not appear to adversely affect 30-day outcomes.